hrp0095p2-307 | Late Breaking | ESPE2022

Hypoglycemia as a result of skewed thiopurine metabolism in two pediatric patients

Seong Clara , Giordano Lisa , Seyboth Brian , Minutti Carla

Introduction: 6 Mercaptopurine (6MP) is a cornerstone of maintenance therapy in pediatric acute lymphoblastic leukemia (ALL). Fasting hypoglycemia is a rare side effect of 6MP therapy that has been observed in children being treated for ALL. We present two pediatric patients who developed symptomatic, fasting hypoglycemia during maintenance therapy.Case Description: A 7-year-old male with standard risk B ALL receiving ma...